The Role of the Vitamin D Receptor

About VDR

The vitamin D receptor (VDR) is a healthy proteins that binds to it is ligand one particular, 25-dihydroxyvitamin D3 and adjusts gene expression by assaulting specific family genes. It is a primary regulatory component in the response of any cellular immunity mechanism to triggered T cells or tumor cells. Moreover, it is a central molecule in the transcriptional activation pathway of T cells, regulating both equally gene expression and cytokine secretion by activated T cells.

Variations inside the code region for the VDR gene result in polymorphisms that impact the function within the protein. Allelic variants with the VDR gene have been linked to autoimmune diseases and cancer (Feldman et approach., 2005).

Regulation of the VDR gene can be mediated by various extracellular alerts and is controlled by a various cis-regulatory factors. For example , the VDR gene can be up-regulated in T cells induced by activation from the innate immune system response. This up-regulation can be triggered by the activation of TCRs stated on the surface of antigen-naive T skin cells and co-stimulatory events including mitogen activation or cytokines (von Essen et ‘s., 2010).

VDR is also a vital molecule inside the signaling paths of unsuspecting T cells. Activation of naive To cells by the triggering of T cell receptors about antigen-presenting cellular material and co-stimulatory signals induces up-regulation of VDR, which is further facilitated by 1, 25(OH)2D3-induced upregulation of RNA pol II. This up-regulation of VDR is certainly accompanied by an increase in histon H4 acetylation, which is associated with enhancer parts at the VDR gene locus.